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Absence of cholinergic deficits in "pure" vascular dementia

From Newcastle General Hospital (Drs. E. Perry, Ziabreva, and R. Perry) and Wolfson Centre for Age Related Diseases (Dr. Ballard), Kings College London, UK; and Central Hospital (Dr. Aarsland), Rogaland, Norway.

Address correspondence and reprint requests to Dr. E.K. Perry, Newcastle General Hospital, MRC Bldg., Westgate Rd., Newcastle upon Tyne, NE4 6BE, UK; e-mail: e.k.perry{at}ncl.ac.uk

Choline acetyltransferase in temporal cortex was evaluated as a marker of cholinergic function in autopsied dementia cases (9 vascular dementia [VaD] cases, 12 "mixed" VaD and Alzheimer disease [AD] cases, 10 AD cases, 12 control subjects). Patients with AD (t = 2.5, p = 0.02) and "mixed" VaD and AD (t = 3.8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients.

Received April 6, 2004. Accepted in final form August 17, 2004.

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