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NEUROLOGY 2005;64:139-141
© 2005 American Academy of Neurology
Brief Communications

APOE {epsilon}4 is not a susceptibility gene in idiopathic or diabetic sensory neuropathy

Z. Zhou, BA, A. Hoke, MD, PhD, D. R. Cornblath, MD, J. W. Griffin, MD and M. Polydefkis, MD

From the Departments of Neurology (Z. Zhou, and Drs. Hoke, Cornblath, Griffin, and Polydefkis), Pathology (Dr. Griffin), and Neuroscience (Dr. Griffin), The Johns Hopkins University School of Medicine, Baltimore, MD.

Address correspondence and reprint requests to Dr. Michael Polydefkis, The Johns Hopkins Hospital, Pathology 509, Baltimore, MD 21287; e-mail: mpolyde{at}jhmi.edu

The presence of an APOE {epsilon}4 allele may be a risk factor for neuropathy severity in diabetes. The authors assessed the frequency of APOE {epsilon}4 in patients presenting with sensory predominant neuropathy. APOE {epsilon}4 frequency among patients with early diabetic neuropathy and impaired glucose tolerance–associated neuropathy was 16 to 17%, and not different from patients with idiopathic neuropathy (17%) or published normative values (16%). APOE {epsilon}4 may not function as a susceptibility gene in sensory predominant neuropathy.

Received April 14, 2004. Accepted in final form August 18, 2004.




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