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NEUROLOGY 2005;64:152-153
© 2005 American Academy of Neurology
Brief Communications

Evidence for superior parietal impairment in Williams syndrome

M. A. Eckert, PhD, D. Hu, BS, S. Eliez, MD, U. Bellugi, PhD, A. Galaburda, MD, J. Korenberg, MD, D. Mills, PhD and A. L. Reiss, MD

From the Department of Psychiatry and Behavioral Sciences (Drs. Eckert and Reiss, D. Hu), Stanford University School of Medicine, Palo Alto, CA; Division of Child and Adolescent Psychiatry (Dr. Eliez), Geneva University School of Medicine, Switzerland; Salk Institute Laboratory for Cognitive Neuroscience (Dr. Bellugi), La Jolla, CA; Department of Neurology (Dr. Galaburda), Harvard Medical School, Boston, MA; Department of Pediatrics (Dr. Korenberg), University of California, Los Angeles, CA; and Department of Psychology (Dr. Mills), Emory University, Atlanta, GA.

Address correspondence and reprint requests to Dr. Mark Eckert, 401 Quarry Road, Room 1358, Department of Psychiatry, Stanford University, Stanford, CA 94305; e-mail: meckert{at}stanford.edu

Parietal lobe impairment is hypothesized to contribute to the dramatic visual-spatial deficits in Williams syndrome (WS). The authors examined the superior and inferior parietal lobule in 17 patients with WS and 17 control female adults (CNLs). The right and left superior parietal lobule gray matter volumes were significantly smaller in patients with WS than in CNLs, even after controlling for total cerebral gray matter. Impaired superior parietal function could explain WS visual-spatial and visual-motor problems.

Received April 15, 2004. Accepted in final form August 16, 2004.




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