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Incidence of essential tremor in three elderly populations of central Spain

From the Department of Neurology (Dr. Benito-León), Móstoles General Hospital, Móstoles, Madrid, Spain; Department of Neurology (Dr. Bermejo-Pareja), University Hospital "12 de Octubre", Madrid, Spain; and the G.H. Sergievsky Center and Department of Neurology (Dr. Louis), College of Physicians and Surgeons, Columbia University, New York, NY.

Address correspondence and reprint requests to Dr. Julián Benito-León, Avda. de la Constitución 73, portal 3, 7 Izquierda, E-28820 Coslada, Madrid, Spain; e-mail: jbenitol{at}meditex.es

Objective: To estimate the incidence of essential tremor (ET) in three populations in central Spain using data from the Neurologic Disorders in Central Spain (NEDICES), a population-based survey of elderly subjects (65 years and older).

Methods: Individuals were evaluated at baseline (1994 to 1995) and at follow-up (a median of 3.3 years later in 1997 to 1998). The evaluation included a screening question for ET and a neurologic examination, when possible.

Results: Of 5,278 subjects evaluated at baseline, there were 256 prevalent ET cases. Eighty-three incident ET cases were identified among 3,942 individuals assessed at follow-up. The adjusted annual incidence rate (per 100,000 person-years) in the population aged 65 years and older was 616 (95% CI: 447 to 784). Sixty-four (77.1%) of 83 incident cases had not been diagnosed before our assessment.

Conclusions: The incidence of ET may be higher than previously recognized because a large proportion of patients with ET may never seek medical attention.

*See the Appendix for a list of Group members.

The NEDICES was supported by the Spanish Health Research Agency and the Spanish Office of Science and Technology.

Presented in part at the 54th Annual Meeting of the American Academy of Neurology, Denver, CO, April 13-20, 2002.

Received December 8, 2004. Accepted in final form February 8, 2005.

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