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NEUROLOGY 2005;64:1789-1793
© 2005 American Academy of Neurology
Brief Communications

Nested polymerase chain reaction for assessing the clinical course of tuberculous meningitis

T. Takahashi, MD, T. Nakayama, MD, M. Tamura, MD, K. Ogawa, MD, H. Tsuda, MD, A. Morita, MD, M. Hara, MD, M. Togo, MD, H. Shiota, MD, Y. Suzuki, MD, M. Minami, MD, H. Ishikawa, MD, K. Miki, MD, E. Shikata, MD, S. Takahashi, MD, T. Kuragano, MD, K. Matsumoto, MD, S. Sawada, MD and T. Mizutani, MD

From the Division of Neurology (Drs. T. Takahashi, Tamura, Ogawa, Tsuda, Morita, Hara, Togo, Shiota, Suzuki, Minami, Ishikawa, Miki, Shikata, and Mizutani) and Division of Nephrology and Endocrinology (Drs. S. Takahashi, Kuragano, and Matsumoto), Department of Medicine, and Division of Receptor Biology, Advanced Medical Research Center (Dr. Nakayama), Nihon University School of Medicine; and Department of Internal Medicine (Dr. Sawada), Nihon University Nerima-Hikarigaoka Hospital, Tokyo, Japan.

Address correspondence and reprint requests to Dr. Tomohiro Nakayama, Division of Receptor Biology, Advanced Medical Research Center, Nihon University School of Medicine, Ooyaguchi-kamimachi 30-1, Itabashi-ku, Tokyo 173-8610, Japan; e-mail: tnakayam{at}med.nihon-u.ac.jp

The authors examined the usefulness of nested PCR (N-PCR) to detect Mycobacterium tuberculosis (MTB) DNA in CSF for assessing the clinical course of tuberculous meningitis (TBM). N-PCR successfully detected MTB DNA in all nine CSF samples from patients with suspected TBM. During anti-tuberculosis treatments, N-PCR results converted from positive to negative, correlating with the improvement of the patient’s clinical condition.

Supported by a grant from the Ministry of Education, Science and Culture of Japan (High-Tech Research Center, Nihon University).

Received November 4, 2004. Accepted in final form February 2, 2005.




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