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Evaluation of urinary PrP^Sc as a diagnostic test for sporadic, variant, and familial CJD

From the National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, UK.

Address correspondence and reprint requests to Dr Head, National CJD Surveillance Unit, Bryan Matthews Bldg., Western General Hospital, Edinburgh, EH4 2XU, UK; e-mail: m.w.head{at}ed.ac.uk

Previously collected urine specimens from 100 patients referred to the UK National CJD Surveillance Unit as suspected cases of Creutzfeldt–Jakob disease (CJD) were analyzed, testing for abnormal prion protein (PrP^Sc). In this context, the test had a low sensitivity and was not completely specific for CJD. Additionally, the proteins detected by this assay were not PrP^Sc but appeared to be immunoglobulins.

Supported by a Department of Health contract (DH 0070064) (M.W.H., R.K.) and by the UK Department of Health and the Scottish Executive (UK National CJD Surveillance Unit).

Received December 21, 2004. Accepted in final form February 4, 2005.

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