|
|
||||||||
From the Harvard Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Physical Medicine and Rehabilitation and Psychiatry Institute, University of Sao Paulo, Sao Paulo, Brazil.
Address correspondence and reprint requests to Dr. Felipe Fregni, Harvard Center for Non-invasive Brain Stimulation, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, KS 433, Boston, MA 02215; e-mail: ffregni{at}bidmc.harvard.edu
The authors investigated the use of slow-frequency repetitive transcranial magnetic stimulation (rTMS) to the unaffected hemisphere to decrease interhemispheric inhibition of the lesioned hemisphere and improve motor function in patients within 12 months of a stroke. Patients showed a significant decrease in simple and choice reaction time and improved performance of the Purdue Pegboard test with their affected hand after rTMS of the motor cortex in the intact hemisphere as compared with sham rTMS.
*These authors contributed equally to this work.
Supported by the Harvard Thorndike General Clinical Research Center (NCRR MO1 RR01032) at Beth Israel Deaconess Medical Center, by a grant within the Harvard Medical School Scholars in Clinical Sciences Program (NIH K30 HL004095-03) to F.F., and by K24 RR018875, RO1-NS 47754, and RO1-NS 20068 to A.P.-L.
Received October 12, 2004. Accepted in final form January 27, 2005.
Related Article
Neurology 2005 64: 1672-1673.
This article has been cited by other articles:
![]() |
V. Di Lazzaro, P. Profice, F. Pilato, F. Capone, F. Ranieri, P. Pasqualetti, C. Colosimo, E. Pravata, A. Cianfoni, and M. Dileone Motor Cortex Plasticity Predicts Recovery in Acute Stroke Cereb Cortex, October 5, 2009; (2009) bhp216v1. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. G. Lindberg, J. Gaverth, A. Fagergren, P. Fransson, H. Forssberg, and J. Borg Cortical Activity in Relation to Velocity Dependent Movement Resistance in the Flexor Muscles of the Hand After Stroke Neurorehabil Neural Repair, October 1, 2009; 23(8): 800 - 810. [Abstract] [PDF] |
||||
![]() |
D. A. Nowak, C. Grefkes, M. Ameli, and G. R. Fink Interhemispheric Competition After Stroke: Brain Stimulation to Enhance Recovery of Function of the Affected Hand Neurorehabil Neural Repair, September 1, 2009; 23(7): 641 - 656. [Abstract] [PDF] |
||||
![]() |
P. Ragert, M. Camus, Y. Vandermeeren, M. A. Dimyan, and L. G. Cohen Modulation of Effects of Intermittent Theta Burst Stimulation Applied Over Primary Motor Cortex (M1) by Conditioning Stimulation of the Opposite M1 J Neurophysiol, August 1, 2009; 102(2): 766 - 773. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Castel-Lacanal, P. Marque, J. Tardy, X. de Boissezon, V. Guiraud, F. Chollet, I. Loubinoux, and M. Simonetta-Moreau Induction of Cortical Plastic Changes in Wrist Muscles by Paired Associative Stimulation in the Recovery Phase of Stroke Patients Neurorehabil Neural Repair, May 1, 2009; 23(4): 366 - 372. [Abstract] [PDF] |
||||
![]() |
E. B. Plow, J. R. Carey, R. J. Nudo, and A. Pascual-Leone Invasive Cortical Stimulation to Promote Recovery of Function After Stroke: A Critical Appraisal Stroke, May 1, 2009; 40(5): 1926 - 1931. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Rizzo, H.S. Siebner, F. Morgante, C. Mastroeni, P. Girlanda, and A. Quartarone Paired Associative Stimulation of Left and Right Human Motor Cortex Shapes Interhemispheric Motor Inhibition based on a Hebbian Mechanism Cereb Cortex, April 1, 2009; 19(4): 907 - 915. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Avanzino, M. Bove, A. Tacchino, C. Trompetto, C. Ogliastro, and G. Abbruzzese Interaction Between Finger Opposition Movements and Aftereffects of 1Hz-rTMS on Ipsilateral Motor Cortex J Neurophysiol, March 1, 2009; 101(3): 1690 - 1694. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. L. Harvey, C. J. Winstein, and for the Everest Trial Group Design for the Everest Randomized Trial of Cortical Stimulation and Rehabilitation for Arm Function Following Stroke Neurorehabil Neural Repair, January 1, 2009; 23(1): 32 - 44. [Abstract] [PDF] |
||||
![]() |
A. Floel, F. Hummel, J. Duque, S. Knecht, and L. G. Cohen Influence of Somatosensory Input on Interhemispheric Interactions in Patients With Chronic Stroke Neurorehabil Neural Repair, September 1, 2008; 22(5): 477 - 485. [Abstract] [PDF] |
||||
![]() |
D. A. Nowak, C. Grefkes, M. Dafotakis, S. Eickhoff, J. Kust, H. Karbe, and G. R. Fink Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation of the Contralesional Primary Motor Cortex on Movement Kinematics and Neural Activity in Subcortical Stroke Arch Neurol, June 1, 2008; 65(6): 741 - 747. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Hiscock, S. Miller, J. Rothwell, R. C. Tallis, and V. M. Pomeroy Informing Dose-Finding Studies of Repetitive Transcranial Magnetic Stimulation to Enhance Motor Function: A Qualitative Systematic Review Neurorehabil Neural Repair, June 1, 2008; 22(3): 228 - 249. [Abstract] [PDF] |
||||
![]() |
J Duque, R Mazzocchio, K Stefan, F Hummel, E Olivier, and L. G. Cohen Memory Formation in the Motor Cortex Ipsilateral to a Training Hand Cereb Cortex, June 1, 2008; 18(6): 1395 - 1406. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. M. Stinear, P. A. Barber, J. P. Coxon, M. K. Fleming, and W. D. Byblow Priming the motor system enhances the effects of upper limb therapy in chronic stroke Brain, May 1, 2008; 131(5): 1381 - 1390. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. R. Carey, C. D. Evans, D. C. Anderson, E. Bhatt, A. Nagpal, T. J. Kimberley, and A. Pascual-Leone Safety of 6-Hz Primed Low-Frequency rTMS in Stroke Neurorehabil Neural Repair, April 1, 2008; 22(2): 185 - 192. [Abstract] [PDF] |
||||
![]() |
J. D. Schaechter and K. L. Perdue Enhanced Cortical Activation in the Contralesional Hemisphere of Chronic Stroke Patients in Response to Motor Skill Challenge Cereb Cortex, March 1, 2008; 18(3): 638 - 647. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. B. Nielsen and L. G. Cohen The olympic brain. Does corticospinal plasticity play a role in acquisition of skills required for high-performance sports? J. Physiol., January 1, 2008; 586(1): 65 - 70. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. M. Pomeroy, G. Cloud, R. C. Tallis, C. Donaldson, V. Nayak, and S. Miller Transcranial Magnetic Stimulation and Muscle Contraction to Enhance Stroke Recovery: A Randomized Proof-of-Principle and Feasibility Investigation Neurorehabil Neural Repair, December 1, 2007; 21(6): 509 - 517. [Abstract] [PDF] |
||||
![]() |
A. J Butler and S. L Wolf Putting the Brain on the Map: Use of Transcranial Magnetic Stimulation to Assess and Induce Cortical Plasticity of Upper-Extremity Movement Physical Therapy, June 1, 2007; 87(6): 719 - 736. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. R. Carey, W. K. Durfee, E. Bhatt, A. Nagpal, S. A. Weinstein, K. M. Anderson, and S. M. Lewis Comparison of Finger Tracking Versus Simple Movement Training via Telerehabilitation to Alter Hand Function and Cortical Reorganization After Stroke Neurorehabil Neural Repair, May 1, 2007; 21(3): 216 - 232. [Abstract] [PDF] |
||||
![]() |
L. Winhuisen, A. Thiel, B. Schumacher, J. Kessler, J. Rudolf, W. F. Haupt, and W. D. Heiss The Right Inferior Frontal Gyrus and Poststroke Aphasia: A Follow-Up Investigation Stroke, April 1, 2007; 38(4): 1286 - 1292. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. M. Rossini and S. Rossi Transcranial magnetic stimulation: Diagnostic, therapeutic, and research potential Neurology, February 13, 2007; 68(7): 484 - 488. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Hotermans, P. Peigneux, G. Moonen, A. Maertens de Noordhout, and P. Maquet Therapeutic Use of High-Frequency Repetitive Transcranial Magnetic Stimulation in Stroke Stroke, February 1, 2007; 38(2): 253 - 253. [Full Text] [PDF] |
||||
![]() |
C. M. Stinear, P. A. Barber, P. R. Smale, J. P. Coxon, M. K. Fleming, and W. D. Byblow Functional potential in chronic stroke patients depends on corticospinal tract integrity Brain, January 1, 2007; 130(1): 170 - 180. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Fregni, P. S. Boggio, A. C. Valle, R. R. Rocha, J. Duarte, M. J.L. Ferreira, T. Wagner, S. Fecteau, S. P. Rigonatti, M. Riberto, et al. A Sham-Controlled Trial of a 5-Day Course of Repetitive Transcranial Magnetic Stimulation of the Unaffected Hemisphere in Stroke Patients Stroke, August 1, 2006; 37(8): 2115 - 2122. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-H. Kim, S. H. You, M.-H. Ko, J.-W. Park, K. H. Lee, S. H. Jang, W.-K. Yoo, and M. Hallett Repetitive Transcranial Magnetic Stimulation-Induced Corticomotor Excitability and Associated Motor Skill Acquisition in Chronic Stroke Stroke, June 1, 2006; 37(6): 1471 - 1476. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Gerloff, K. Bushara, A. Sailer, E. M. Wassermann, R. Chen, T. Matsuoka, D. Waldvogel, G. F. Wittenberg, K. Ishii, L. G. Cohen, et al. Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke Brain, March 1, 2006; 129(3): 791 - 808. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. S. Ward, J. M. Newton, O. B. C. Swayne, L. Lee, A. J. Thompson, R. J. Greenwood, J. C. Rothwell, and R. S. J. Frackowiak Motor system activation after subcortical stroke depends on corticospinal system integrity Brain, March 1, 2006; 129(3): 809 - 819. [Abstract] [Full Text] [PDF] |
||||
![]() |
W.-D. Heiss and R. W. Teasel Brain Recovery and Rehabilitation Stroke, February 1, 2006; 37(2): 314 - 316. [Full Text] [PDF] |
||||
![]() |
J. T H Teo Don't discount magnet therapy BMJ, January 21, 2006; 332(7534): 180 - 180. [Full Text] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |