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From the Harvard Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and Department of Physical Medicine and Rehabilitation and Psychiatry Institute, University of Sao Paulo, Sao Paulo, Brazil.
Address correspondence and reprint requests to Dr. Felipe Fregni, Harvard Center for Non-invasive Brain Stimulation, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, KS 433, Boston, MA 02215; e-mail: ffregni{at}bidmc.harvard.edu
The authors investigated the use of slow-frequency repetitive transcranial magnetic stimulation (rTMS) to the unaffected hemisphere to decrease interhemispheric inhibition of the lesioned hemisphere and improve motor function in patients within 12 months of a stroke. Patients showed a significant decrease in simple and choice reaction time and improved performance of the Purdue Pegboard test with their affected hand after rTMS of the motor cortex in the intact hemisphere as compared with sham rTMS.
*These authors contributed equally to this work.
Supported by the Harvard Thorndike General Clinical Research Center (NCRR MO1 RR01032) at Beth Israel Deaconess Medical Center, by a grant within the Harvard Medical School Scholars in Clinical Sciences Program (NIH K30 HL004095-03) to F.F., and by K24 RR018875, RO1-NS 47754, and RO1-NS 20068 to A.P.-L.
Received October 12, 2004. Accepted in final form January 27, 2005.
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