| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Psychiatry (Drs. Mosconi, Tsui, De Santi, J. Li, Convit, Y. Li, Boppana, and de Leon) and Radiology (Dr. Rusinek), New York University School of Medicine, New York; Nathan Kline Institute (Drs. Tsui, Convit, and de Leon), Orangeburg, NY; and Department of Clinical Pathophysiology (Dr. Mosconi), Nuclear Medicine Unit, University of Florence, Italy.
Address correspondence and reprint requests to Dr. Mony J. de Leon, Center for Brain Health, MHL400, NY University School of Medicine, 560 First Avenue, New York, NY 10016; e-mail: mony.deleon{at}med.nyu.edu
Background: To facilitate image analysis, most recent 2-[18F]fluoro-2-deoxy-d-glucose PET (FDG-PET) studies of glucose metabolism (MRglc) have used automated voxel-based analysis (VBA) procedures but paradoxically none reports hippocampus MRglc reductions in mild cognitive impairment (MCI) or Alzheimer disease (AD). Only a few studies, those using regions of interest (ROIs), report hippocampal reductions. The authors created an automated and anatomically valid mask technique to sample the hippocampus on PET (HipMask).
Methods: Hippocampal ROIs drawn on the MRI of 48 subjects (20 healthy elderly [NL], 16 MCI, and 12 AD) were used to develop the HipMask. The HipMask technique was applied in an FDG-PET study of NL (n = 11), MCI (n = 13), and AD (n = 12), and compared to both MRI-guided ROIs and VBA methods.
Results: HipMask and ROI hippocampal sampling produced significant and equivalent MRglc reductions for contrasts between MCI and AD relative to NL. The VBA showed typical cortical effects but failed to show hippocampal MRglc reductions in either clinical group. Hippocampal MRglc was the only discriminator of NL vs MCI (78% accuracy) and added to the cortical MRglc in classifying NL vs AD and MCI vs AD.
Conclusions: The new HipMask technique provides accurate and rapid assessment of the hippocampus on PET without the use of regions of interest. Hippocampal glucose metabolism reductions are found in both mild cognitive impairment and Alzheimer disease and contribute to their diagnostic classification. These results suggest re-examination of prior voxel-based analysis 2-[18F]fluoro-2-deoxy-d-glucose PET studies that failed to report hippocampal effects.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the June 14 issue to find the title link for this article.
Supported by NIH-NIA grants AG12101, AG13613, and AG08051.
Received October 1, 2004. Accepted in final form February 8, 2005.
This article has been cited by other articles:
|
|
 |
|
  V. J. Lowe, B. J. Kemp, C. R. Jack Jr., M. Senjem, S. Weigand, M. Shiung, G. Smith, D. Knopman, B. Boeve, B. Mullan, et al. Comparison of 18F-FDG and PiB PET in Cognitive Impairment J. Nucl. Med., June 1, 2009; 50(6): 878 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. B. Frisoni, M. Lorenzi, A. Caroli, N. Kemppainen, K. Nagren, and J. O. Rinne In vivo mapping of amyloid toxicity in Alzheimer disease Neurology, April 28, 2009; 72(17): 1504 - 1511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Minati, T. Edginton, M. Grazia Bruzzone, and G. Giaccone Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review American Journal of Alzheimer's Disease and Other Dementias, April 1, 2009; 24(2): 95 - 121. [Abstract] [PDF]
|
|
|
|
|
|
L. Mosconi, R. Mistur, R. Switalski, M. Brys, L. Glodzik, K. Rich, E. Pirraglia, W. Tsui, S. De Santi, and M. J. de Leon Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease Neurology, February 10, 2009; 72(6): 513 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gimenez-Cassina, F. Lim, T. Cerrato, G. M. Palomo, and J. Diaz-Nido Mitochondrial Hexokinase II Promotes Neuronal Survival and Acts Downstream of Glycogen Synthase Kinase-3 J. Biol. Chem., January 30, 2009; 284(5): 3001 - 3011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mikhno, D. Devanand, G. Pelton, K. Cuasay, R. Gunn, N. Upton, R. Y. Lai, V. Libri, J. J. Mann, and R. V. Parsey Voxel-Based Analysis of 11C-PIB Scans for Diagnosing Alzheimer's Disease J. Nucl. Med., August 1, 2008; 49(8): 1262 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Mosconi, W. H. Tsui, K. Herholz, A. Pupi, A. Drzezga, G. Lucignani, E. M. Reiman, V. Holthoff, E. Kalbe, S. Sorbi, et al. Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias J. Nucl. Med., March 1, 2008; 49(3): 390 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Chetelat, B. Desgranges, B. Landeau, F. Mezenge, J. B. Poline, V. de la Sayette, F. Viader, F. Eustache, and J.-C. Baron Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease Brain, January 1, 2008; 131(1): 60 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K HERHOLZ, S F CARTER, and M JONES Positron emission tomography imaging in dementia Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S160 - S167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Mosconi, M. Brys, R. Switalski, R. Mistur, L. Glodzik, E. Pirraglia, W. Tsui, S. De Santi, and M. J. de Leon From the Cover: Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism PNAS, November 27, 2007; 104(48): 19067 - 19072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsuda Role of Neuroimaging in Alzheimer's Disease, with Emphasis on Brain Perfusion SPECT J. Nucl. Med., August 1, 2007; 48(8): 1289 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Mosconi, W. H. Tsui, A. Pupi, S. De Santi, A. Drzezga, S. Minoshima, and M. J. de Leon 18F-FDG PET Database of Longitudinally Confirmed Healthy Elderly Individuals Improves Detection of Mild Cognitive Impairment and Alzheimer's Disease J. Nucl. Med., July 1, 2007; 48(7): 1129 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ishii, T. Soma, A. K. Kono, K. Sofue, N. Miyamoto, T. Yoshikawa, E. Mori, and K. Murase Comparison of Regional Brain Volume and Glucose Metabolism Between Patients with Mild Dementia with Lewy Bodies and Those with Mild Alzheimer's Disease J. Nucl. Med., May 1, 2007; 48(5): 704 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Edison, H. A. Archer, R. Hinz, A. Hammers, N. Pavese, Y. F. Tai, G. Hotton, D. Cutler, N. Fox, A. Kennedy, et al. Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study Neurology, February 13, 2007; 68(7): 501 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Mosconi, S. Sorbi, M. J. de Leon, Y. Li, B. Nacmias, P. S. Myoung, W. Tsui, A. Ginestroni, V. Bessi, M. Fayyazz, et al. Hypometabolism Exceeds Atrophy in Presymptomatic Early-Onset Familial Alzheimer's Disease J. Nucl. Med., November 1, 2006; 47(11): 1778 - 1786. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Arehart-Treichel Research Findings Lead to Test To Detect Early Alzheimer's Psychiatr News, August 5, 2005; 40(15): 33 - 33. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
