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NEUROLOGY 2005;64:1944-1945
© 2005 American Academy of Neurology


Brief Communications

High titers of CA-125 may be associated with recurrent ischemic strokes in patients with cancer

T. G. Jovin, MD, V. Boosupalli, MD, S. A. Zivkovic, MD, L. R. Wechsler, MD and J. M. Gebel, MD

From the Stroke Institute (Drs. Jovin, Wechsler, and Gebel) and Department of Neurology (Drs. Jovin, Zivkovic, and Wechsler), University of Pittsburgh Medical Center, VA Pittsburgh Healthcare System (Drs. Jovin and Zivkovic), and Department of Neurology (Dr. Boosupalli), Children's Hospital of Pittsburgh, PA.

Address correspondence and reprint requests to Dr Jovin, UPMC Stroke Institute, 200 Lothrop St., Suite C400, Pittsburgh, PA 15213-2582; e-mail: jovintg{at}upmc.edu

In addition to etiologies common in the general population, strokes in cancer patients may be caused by hypercoagulable states, hyperviscosity, cardiogenic embolism, and neoplastic vessel infiltration. Intravascular mucins were reported in patients with recurrent thromboembolism. The authors report four patients with metastatic cancer, brain infarcts, and other thromboembolic disease with markedly elevated levels of the tumor marker CA-125 and explore possible associations between this mucinous protein and strokes.


Received October 1, 2004. Accepted in final form February 11, 2005.







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