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NEUROLOGY 2005;64:1971-1973
© 2005 American Academy of Neurology
Brief Communications

Reversible impaired memory induced by pulsed methylprednisolone in patients with MS

I. Uttner, PhD, S. Müller, BA, C. Zinser, MSc, M. Maier, MD, S. Süßmuth, MD, A. Claus, MD, B. Ostermann, MD, E. Elitok, MD, D. Ecker, MD, J. Brettschneider, MD, R. Gold, MD and H. Tumani, MD

From the Neurologische Klinik der Universität Ulm I (Drs. Uttner, Maier, Süßmuth, Claus, Ostermann, Elitok, Ecker, Brettschneider, and Tumani, S. Müller and C. Zinser), and Institut für MS-Forschung (Dr. Gold), Universität Göttingen und Gemeinnützige Hertie-Stiftung, Germany.

Address correspondence and reprint requests to Dr. I. Uttner and Dr. H. Tumani, Neurologische Klinik der Universität Ulm Rehabilitationskrankenhaus Oberer Eselsberg 45 D-89081 Ulm, Germany; e-mail: ingo.uttner{at}medizin.uni-ulm.de or hayrettin.tumani{at}medizin.uni-ulm.de

Thirty patients with multiple sclerosis were randomized to 500 or 2,000 mg of methylprednisolone (MP) over 5 days. They were prospectively studied neuropsychologically before and at days 6 and 60 after onset of the therapy, using a double-blind study design. Patients showed selective deterioration of declarative memory retrieval at day 6, which was fully reversible at day 60. Although the sample size was small, these effects were independent of the administered MP dose.

Received October 14, 2004. Accepted in final form February 16, 2005.




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