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Prognosis 30 years after temporal lobectomy

From the Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD.

Address correspondence and reprint requests to Dr. William H. Theodore, NIH Clinical Epilepsy Section, NIH Building 10, Room 5N-250, Bethesda, MD 20892; e-mail: theodorw{at}ninds.nih.gov

To assess the long-term outcome after temporal lobectomy, the authors obtained information from 48 patients and families traced though the NIH Medical Records Department, Social Security, National Death Indices, and other sources. Preoperative evaluation, limited by current standards, was based mainly on interictal surface EEG. After a mean 29.9-year follow-up, 24 were seizure free, and 10 had died. Early seizure recurrence and invasive EEG studies predicted worse long-term outcome.

Received August 26, 2004. Accepted in final form February 15, 2005.

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