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Published online before print May 25, 2005, doi:10.1212/01.WNL.0000166950.35189.5E)
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NEUROLOGY 2005;64:2029-2032
© 2005 American Academy of Neurology
Views & Reviews

Infant botulism in the age of botulism immune globulin

J. A. Thompson, MD, F. M. Filloux, MD, C. B. Van Orman, MD, K. Swoboda, MD, P. Peterson, PNP, S. D. Firth, PhD, MPH and J. F. Bale, Jr, MD

From the Division of Pediatric Neurology, Department of Pediatrics, The University of Utah and Primary Children’s Medical Center, Salt Lake City.

Address correspondence and reprint requests to Dr. Joel A. Thompson, Division of Pediatric Neurology, Primary Children’s Medical Center, Salt Lake City, UT 84113; e-mail: joel.thompson{at}hsc.utah.edu

Infant botulism causes acute bulbar dysfunction, weakness, and respiratory failure in infants living in endemic regions of the United States. Until Food and Drug Administration approval of botulism immune globulin (BIG) in October 2003, management of infant botulism had changed little since the 1970s. Currently, IV therapy with BIG is advised to shorten the duration and diminish the potential complications of the disorder. This review describes two decades of experience with infant botulism and provides a contemporary perspective on the role and benefit of BIG.

Received June 24, 2004. Accepted in final form March 18, 2005.




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