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NEUROLOGY 2005;64:2132-2133
© 2005 American Academy of Neurology
Brief Communications

"Applause sign" helps to discriminate PSP from FTD and PD

B. Dubois, MD, A. Slachevsky, MD, PhD, B. Pillon, PhD, MD, R. Beato, MD, J. M. Villalponda and I. Litvan, MD

From INSERM U 610 and Fédération de Neurologie (Drs. DuBois, Slachevsky, Pillon, Beato, and Villalponda), Hôpital de la Salpêtrière, Paris, France; Dementia and Cognitive Neurology Unit (Dr. Slachevsky), Neurology Department, Hospital del Salvador, Santiago, Chile; and Movement Disorder Program (Dr. Litvan), University of Louisville, Louisville, KY.

Address correspondence and reprint requests to Dr. Bruno Dubois, INSERM U 610, Pavillon Claude Bernard, Hôpital de la Salpêtrière, 47 Bd. de l’Hôpital, 75013 Paris, France; e-mail: b.dubois{at}psl.ap-hop-paris.fr

The "applause sign" is a simple test of motor control that helps to differentiate PSP from frontal or striatofrontal degenerative diseases. It was found in 0/39 controls, 0 of 24 patients with frontotemporal dementia (FTD), 0 of 17 patients with Parkinson disease (PD), and 30/42 patients with progressive supranuclear palsy (PSP). It discriminated PSP from FTD (p < 0.001) and PD (p < 0.00). The "three clap test" correctly identified 81.8% of the patients in the comparison PSP and FTD and 75% of the patients in the comparison of PSP and PD.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the June 28 issue to find the title link for this article.

A. Slachevsky was funded by a grant from the Fondation de la Recherche Medicale.

Received April 28, 2004. Accepted in final form March 7, 2005.




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