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NEUROLOGY 2005;64:2134-2135
© 2005 American Academy of Neurology
Brief Communications

Depression is associated with impairment of ADL, not motor function in Parkinson disease

Suzanne Holroyd, MD, Lillian J. Currie, PhD, RN and G. Frederick Wooten, MD

From the Departments of Psychiatric Medicine (Dr. Holroyd) and Neurology (Drs. Currie and Wooten), University of Virginia Health System, University of Virginia Health System, Charlottesville, VA.

Address correspondence and reprint requests to Dr. Suzanne Holroyd, Box 800623, University of Virginia Health System, Charlottesville, VA 22908; e-mail: sh4s{at}virginia.edu

Depression was diagnosed in 15% of 100 consecutive patients with Parkinson disease (PD). Depression was associated with lower cognition, history of depression, and a higher Unified Parkinson’s Disease Rating Scale score. The latter was due to differences in the activities of daily living (ADL) subscale (17 ± 7 vs 12 ± 6; p = 0.004) rather than the motor subscale (30 ± 13 vs 26 ± 13; p = 0.27). These results suggest that ADL impairment may in part be due to depression. Patients with PD with poor function should be closely evaluated for depression.

Supported in part by NIH NINDS R01 NS045008-01 A1, NIH NINDS P50 NS 39788, and the American Parkinson Disease Association.

Received January 12, 2005. Accepted in final form March 15, 2005.




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Y. Iwasaki, K. Ikeda, O. Igarashi, S. Baba, S. Holroyd, and L. J. Currie
Depression is associated with impairment of ADL, not motor function in Parkinson disease
Neurology, March 28, 2006; 66(6): 956 - 956.
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Depression is associated with impairment of ADL, not motor function in Parkinson disease
Yasuo Iwasaki, et al.
Neurology Online, 27 Oct 2005 [Full text]
Reply to Iwasaki et al
Suzanne Holroyd, et al.
Neurology Online, 27 Oct 2005 [Full text]

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