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NEUROLOGY 2005;64:344-346
© 2005 American Academy of Neurology
Brief Communications

Treatment of severe tardive dystonia with pallidal deep brain stimulation

T. Trottenberg, MD, J. Volkmann, MD, G. Deuschl, MD, A. A. Kühn, MD, G. -H. Schneider, MD, J. Müller, MD, F. Alesch, MD and A. Kupsch, MD

From the Departments of Neurology (Drs. Trottenberg, Kühn, and Kupsch) and Neurosurgery (Dr. Schneider), Charité Campus Virchow, Humboldt University, Berlin, and Department of Neurology (Drs. Volkmann and Deuschl), Christian Albrechts University, Kiel, Germany; and Department of Neurology (Dr. Müller), University Hospital Innsbruck, and Department of Neurosurgery (Dr. Alesch), University Hospital Vienna, Austria.

Address correspondence and reprint requests to Dr. T. Trottenberg, Department of Neurology, Charité, Universitätsmedizin Berlin, Campus Virchow Klinikum, 13353 Berlin, Germany; e-mail: thomas.trottenberg{at}charite.de

In five patients with medically refractory tardive dystonia, continuous bilateral high-frequency stimulation of the globus pallidus internus was associated with a rapid (within 12 to 72 hours) and substantial (mean 87%, 10.7 SD of the motor part of the Burke–Fahn–Marsden Dystonia Rating Scale) improvement of dystonia and functional disability without adverse events.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the January 25 issue to find the title link for this article.

Received May 17, 2004. Accepted in final form August 24, 2004.




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