Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Asanuma, K.
Right arrow Articles by Eidelberg, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Asanuma, K.
Right arrow Articles by Eidelberg, D.
Related Collections
Right arrow PET
Right arrow Dystonia
Right arrow All Genetics
NEUROLOGY 2005;64:347-349
© 2005 American Academy of Neurology
Brief Communications

Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation

K. Asanuma, MD, Y. Ma, PhD, J. Okulski, BS, V. Dhawan, PhD, T. Chaly, PhD, M. Carbon, MD, S. B. Bressman, MD and D. Eidelberg, MD

From the Center for Neurosciences (Drs. Asanuma, Ma, Dhawan, Chaly, Carbon, and Eidelberg, and J. Okulski), North Shore–Long Island Jewish Research Institute; Department of Neurology (Drs. Ma, Dhawan, Chaly, and Eidelberg), North Shore University Hospital and New York University School of Medicine; and Department of Neurology (Dr. Bressman), Beth Israel Medical Center, New York, NY.

Address correspondence and reprint requests to Dr. David Eidelberg, Center for Neurosciences, North Shore–Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030; e-mail: david1{at}nshs.edu

To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.

Supported by NIH RO1 NS 37564 and the Bachmann-Strauss Dystonia and Parkinson Foundation.

Received April 9, 2004. Accepted in final form August 30, 2004.




This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
A Quartarone, F Morgante, A Sant'Angelo, V Rizzo, S Bagnato, C Terranova, H R Siebner, A Berardelli, and P Girlanda
Abnormal plasticity of sensorimotor circuits extends beyond the affected body part in focal dystonia
J. Neurol. Neurosurg. Psychiatry, September 1, 2008; 79(9): 985 - 990.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Carbon, M. F. Ghilardi, M. Argyelan, V. Dhawan, S. B. Bressman, and D. Eidelberg
Increased cerebellar activation during sequence learning in DYT1 carriers: an equiperformance study
Brain, January 1, 2008; 131(1): 146 - 154.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Feigin, C. Tang, Y. Ma, P. Mattis, D. Zgaljardic, M. Guttman, J. S. Paulsen, V. Dhawan, and D. Eidelberg
Thalamic metabolism and symptom onset in preclinical Huntington's disease
Brain, November 1, 2007; 130(11): 2858 - 2867.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. S. Perlmutter and W. T. Thach
Writer's cramp: Questions of causation
Neurology, July 24, 2007; 69(4): 331 - 332.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by AAN Enterprises, Inc.