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Efficacy of rapid IV administration of valproic acid for status epilepticus

From the University of Alabama School of Medicine (Drs. Limdi, Shimpo, and Faught), Birmingham, AL; Brookwood Hospital (Dr. Gomez), Birmingham, AL; Epilepsy Program (Dr. Burneo), University of Western Ontario, London Health Sciences Center, London, Ontario, Canada.

Address correspondence and reprint requests to Dr. Nita Limdi, UAB Epilepsy Center, Civitan International Research Center, Room 312, 1719 6th Avenue South, Birmingham, AL 35294-0021; e-mail: nlimdi{at}uab.edu

Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose. The authors reviewed 63 patients (30 men) with SE treated with IV VPA (average dose, 31.5 mg/kg). Analysis of demographic, clinical, and treatment information indicated an overall efficacy of 63.3% and favorable tolerance of rapid administration.

Received March 8, 2004. Accepted in final form September 7, 2004.

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