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NEUROLOGY 2005;64:359-360
© 2005 American Academy of Neurology
Brief Communications

The association of depression with disease course in multiple sclerosis

Rana K. Zabad, MD, Scott B. Patten, MD, PhD and Luanne M. Metz, MD

From the Departments of Clinical Neurosciences (Drs. Zabad and Metz), Community Health Sciences (Dr. Patten), and Psychiatry (Dr. Patten), University of Calgary, Alberta, Canada.

Address correspondence and reprint requests to Dr. Luanne M. Metz, Department of Clinical Neurosciences, Foothills Medical Centre, 1403 29th Street NW, Calgary, Alberta, Canada T2N 2T9; e-mail: lmetz{at}ucalgary.ca

The relative frequency of depression in people with primary progressive multiple sclerosis (PPMS) (30 patients) compared with those with a history of relapse (106 patients) was determined. Three participants in the progressive group and 28 in the relapsing group had a lifetime history of major depression. The lifetime morbidity ratio for major depression in relapsing patients was 2.64 compared with that of PPMS.

Supported by the Multiple Sclerosis Society of Canada.

Dr. Zabad has received fellowship support from the Multiple Sclerosis Society of Canada and Biogen Canada. Dr. Patten is funded by the Alberta Heritage Foundation for Medical Research.

Received May 14, 2004. Accepted in final form August 20, 2004.




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