Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edwards-Lee, T.
Right arrow Articles by Hardy, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edwards-Lee, T.
Right arrow Articles by Hardy, J.
Related Collections
Right arrow Alzheimer's disease
Right arrow All Genetics
NEUROLOGY 2005;64:377-379
© 2005 American Academy of Neurology
Brief Communications

An African American family with early-onset Alzheimer disease and an APP (T714I) mutation

T. Edwards-Lee, MD, J. M. Ringman, MD, J. Chung, MD, J. Werner, BS, A. Morgan, PhD, P. St. George Hyslop, MD, P. Thompson, PhD, R. Dutton, BA, A. Mlikotic, MD, E. Rogaeva, PhD and J. Hardy, PhD

From the Departments of Neurology and Psychiatry and Radiology (Drs. Edwards-Lee, Chung, and Mlikotic), Harbor–UCLA Medical Center, Torrance, and Laboratory of Neuroimaging (Drs. Thompson and Dutton), Department of Neurology (Dr. Ringman), University of California at Los Angeles, and Laboratory of Neurogenetics (Drs. Werner and Hardy), National Institute on Aging, NIH, Bethesda, MD; and Centre for Research in Neurodegenerative Diseases (Drs. Morgan, St. George Hyslop, and Rogaeva), University of Toronto, and Division of Neurology (Dr. St. George Hyslop), Department of Medicine, University Health Network, Toronto, Ontario, Canada.

Address correspondence and reprint requests to Dr. J. Hardy at Laboratory of Neurogenetics, National Institute on Aging, NIH, Bldg. 35, Rm. 1A1015, Bethesda, MD 20892; hardyj{at}mail.nih.gov

The occurrence of an APP T174I mutation is described in a large American family of African descent with Alzheimer disease. The clinical characteristics were an unusually early onset of disease (early 30s), similar to a previously reported age at onset of this mutation in an Austrian family. Distinct from that family, seizures and myoclonus were prominent features of the disease in this kindred.

Supported by the National Institute on Aging (NIA) Intramural Program and the DIADEM Consortium/Verum Foundation (J.W., J.H.); grants from the Canadian Institutes of Health Research, Alzheimer Society of Canada, Howard Hughes Medical Institute, and Canadian Genetic Diseases Network (P.S.G.H., E.R.); and the NIH (NIA K08 AG 22228) (J.M.R.).

Received April 29, 2004. Accepted in final form August 20, 2004.




This article has been cited by other articles:


Home page
 J Geriatr Psychiatry NeurolHome page
J. M. Ringman
What the Study of Persons At Risk for Familial Alzheimer's Disease Can Tell Us About the Earliest Stages of the Disorder: A Review
J Geriatr Psychiatry Neurol, December 1, 2005; 18(4): 228 - 233.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
B. J. Snider, J. Norton, M. A. Coats, S. Chakraverty, C. E. Hou, R. Jervis, C. L. Lendon, A. M. Goate, D. W. McKeel Jr, and J. C. Morris
Novel Presenilin 1 Mutation (S170F) Causing Alzheimer Disease With Lewy Bodies in the Third Decade of Life
Arch Neurol, December 1, 2005; 62(12): 1821 - 1830.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by AAN Enterprises, Inc.