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NEUROLOGY 2005;64:386-388
© 2005 American Academy of Neurology
Brief Communications

Combined IV and intra-arterial thrombolysis for acute ischemic stroke

M. L. Flaherty, MD, D. Woo, MD, B. Kissela, MD, E. Jauch, MD, A. Pancioli, MD, J. Carrozzella, RN, J. Spilker, RN, P. Sekar, MS, J. Broderick, MD and T. Tomsick, MD

From the Departments of Neurology (Drs. Flaherty, Woo, Kissela, and Broderick, J. Carrozzella), Emergency Medicine (Drs. Jauch and Pancioli, J. Spilker), Radiology (Dr. Tomsick), and Environment Health (P. Sekar), University of Cincinnati Medical Center, OH.

Address correspondence and reprint requests to Dr. M.L. Flaherty, University of Cincinnati Medical Center, 231 Albert Sabin Way, MSB Rm. 5161B, Cincinnati, OH, 45267-0525; e-mail: matthew.flaherty{at}uc.edu

Combined IV and intra-arterial (IA) thrombolysis for acute ischemic stroke may offer advantages over either technique alone. Sixty-two nonrandomized patients with NIH Stroke Scale scores of ≥10 who met standard criteria for IV thrombolysis were treated with an IV/IA approach. Three-month modified Rankin Scale scores were 0 to 2 for 50% of patients, mortality was 18%, and symptomatic intracerebral hemorrhage occurred in 8%. IV/IA thrombolysis appeared safe and effective in this group.

Dr. B. Kissela has received honoraria from Genentech.

Received July 23, 2004. Accepted in final form September 15, 2004.




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