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From the Headache Center (Drs. Torelli and Manzoni), Section of Neurology, Department of Neuroscience, University of Parma, and "Mario Negri" Institute and Neurological Clinic (Dr. Beghi), University of Milano–Bicocca, Milan, Italy.
Address correspondence and reprint requests to Dr. P. Torelli, Headache Center, Section of Neurology, c/o Ospedale Maggiore, Padiglione Barbieri, Via Gramsci, 14, 43100 Parma, Italy; e-mail: paolatorelli{at}libero.it
Background: Prevalence of cluster headache (CH) is estimated at 56 to 69 per 100,000.
Objective: To calculate the CH lifetime prevalence in a sample representative of the Italian general population over age 14 years.
Methods: Possible CH cases according to the diagnostic criteria of the 1988 International Headache Society classification were screened from a sample of 10,071 patients (5,311 women and 4,760 men; mean age 50.4 years, SD 19.7 years) registered in the lists of seven Parma-based general practitioners (GPs), using a previously validated, specially designed, self-administered questionnaire.
Results: Seven thousand five hundred twenty-two subjects (74.7%; 3,971 women and 3,551 men; mean age 50.8 years, SD 19.0 years) responded to the questionnaire in their GP’s office (n = 3,338; 1,885 women and 1,453 men) or at home by mail (n = 1,914; 1,030 women and 884 men) or by phone (n = 2,270; 1,056 women and 1,214 men). Of the 111 suspected cases (76 women and 35 men), 105 were seen by a neurologist and 6 were contacted on the phone. The diagnosis of CH was confirmed in 21 (9 women and 12 men), including 7 already followed at the authors’ center for CH. Seventeen patients had episodic CH, and four (all men) had chronic CH. The estimated prevalence rate was 279 per 100,000 (95% CI 173 to 427), 227 per 100,000 (95% CI 104 to 431) in women, and 338 per 100,000 (95% CI 175 to 592) in men.
Conclusion: These results point to a higher cluster headache lifetime prevalence than previous reports.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the February 8 issue to find the title link for this article.
Supported by GlaxoSmithKline Italia.
Received July 8, 2004. Accepted in final form October 21, 2004.
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