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NEUROLOGY 2005;64:545-547
© 2005 American Academy of Neurology
Brief Communications

Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease

S. Zaja-Milatovic, MS, D. Milatovic, PhD, A. M. Schantz, MEd, J. Zhang, MD, PhD, K. S. Montine, PhD, A. Samii, MD, A. Y. Deutch, PhD and T. J. Montine, MD, PhD

From the Departments of Pathology (Drs. Milatovic, Zhang, K.S. Montine, and T.J. Montine, S. Zaja-Milatovic and A.M. Schantz) and Neurology (Dr. Samii), University of Washington School of Medicine, Seattle, WA; and Departments of Psychiatry and Pharmacology (Dr. Deutch), Vanderbilt University Medical Center, Nashville, TN.

Address correspondence and reprint requests to Dr. Thomas J. Montine, Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104; e-mail: tmontine{at}u.washington.edu

Dysfunction of neostriatal medium spiny neurons (MSNs) is hypothesized to underlie late-stage motor complications of Parkinson disease (PD). The authors demonstrate shortened dendrite length of MSNs that was similar in four regions of neostriatum in late-stage PD. In contrast, MSN dendrite spine degeneration was unevenly distributed with the greatest loss in caudal putamen. The authors propose that these structural changes in MSN may contribute to late-stage motor complications of PD.

Supported by the Nancy and Ellsworth Alvord Endowment, the Cheng-Mei Shaw Endowment, and P01 NS044282.

Received July 28, 2004. Accepted in final form September 30, 2004.




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