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NEUROLOGY 2005;64:548-550
© 2005 American Academy of Neurology
Brief Communications

Dehydration confounds the assessment of brain atrophy

T. Duning, MD*, S. Kloska, MD*, O. Steinsträter, PhD, H. Kugel, PhD, W. Heindel, MD and S. Knecht, MD

From the Departments of Neurology (Drs. Duning, Kloska, Steinsträter, and Knecht) and Clinical Radiology (Drs. Kloska, Kugel, and Heindel), University of Münster, Germany.

Address correspondence and reprint requests to Dr. Thomas Duning, University of Muenster, Department of Neurology, Albert-Schweitzer-Str. 22, 48129 Muenster, Germany; e-mail: duningt{at}uni-muenster.de

Computerized brain volumetry has potential value for diagnosis and the follow-up evaluation of degenerative disorders. A potential pitfall of this method is the extent of physiologic variations in brain volume. The authors show that dehydration and rehydration can significantly change brain volume: lack of fluid intake for 16 hours decreased brain volume by 0.55% (SD, ±0.69), and after rehydration total cerebral volume increased by 0.72% (SD, ±0.21).

*These authors contributed equally to this work.

Supported by grants from the German Federal Ministry of Education and Research (Mednet Atrial Fibrillation, S.K.) and the IZKF Muenster (NWG2, S.K.).

Received December 18, 2003. Accepted in final form September 30, 2004.


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