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NEUROLOGY 2005;64:556-557
© 2005 American Academy of Neurology
Brief Communications

Primary progressive aphasia: Reversed asymmetry of atrophy and right hemisphere language dominance

M. Mesulam, MD, S. Weintraub, PhD, T. Parrish, PhD and D. Gitelman, MD

From the Cognitive Neurology and Alzheimer’s Disease Center and the Departments of Neurology, Psychiatry, and Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Address correspondence and reprint requests to Dr. M. Mesulam, 320 East Superior Street, Chicago, IL 60611; e-mail: mmesulam{at}northwestern.edu

Primary progressive aphasia (PPA) is almost always associated with asymmetrical left hemisphere degeneration. The authors report that right hemisphere atrophy in a patient with PPA was associated with atypical right hemisphere dominance for language. This suggests that neuronal damage in PPA is therefore tightly linked to the underlying anatomy of the language network.

Supported by the Alzheimer’s Disease Center from NIA AG-13854.

Received August 6, 2004. Accepted in final form September 9, 2004.






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