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NEUROLOGY 2005;64:564-566
© 2005 American Academy of Neurology
Brief Communications

HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS

E. Cocco, MD, A. Sotgiu, BD, G. Costa, BD, M. R. Murru, BD, C. Mancosu, BD, R. Murru, BD, M. Lai, MD, P. Contu, MD and M. G. Marrosu, MD

From the Centro Sclerosi Multipla (Drs. Cocco, Costa, Murru, Mancosu, Murru, Lai, and Marrosu), Dipartimento di Neuroscienze, and Dipartimento di Salute Pubblica (Drs. Sotgiu and Contu), Università di Cagliari, Italy.

Address correspondence and reprint requests to Dr. M.G. Marrosu, Centro Sclerosi Multipla, Ospedale Binaghi, Via Is Guadazzonis, 2, 09126 Cagliari, Italy; e-mail: gmarrosu{at}unica.it

The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.002) in women carrying the APOE4 but not the DRB1-DQB1 predisposing genotype, suggesting in this subgroup of patients a reciprocal influence between these genes and gender in modulating clinical variability of the disease.

Supported by the Federazione Italiana Sclerosi Multipla (grant no. 2001/R/39).

Received May 10, 2004. Accepted in final form September 21, 2004.




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[Abstract] [Full Text] [PDF]


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