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NEUROLOGY 2005;64:567-570
© 2005 American Academy of Neurology
Brief Communications

Resective surgery to treat refractory status epilepticus in children with focal epileptogenesis

A. Alexopoulos, MD, D. K. Lachhwani, MD, A. Gupta, MD, P. Kotagal, MD, A. M. Harrison, MD, W. Bingaman, MD and E. Wyllie, MD

From the Departments of Neurology (Drs. Alexopoulos, Lachhwani, Gupta, Kotagal, and Wyllie), Pediatric Critical Care Medicine (Dr. Harrison), and Neurosurgery (Dr. Bingaman), The Cleveland Clinic Foundation, Cleveland, OH.

Address correspondence and reprint requests to Dr. Deepak K. Lachhwani, Section of Pediatric Epilepsy and Pediatric Neurology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, S-51, Cleveland, OH 44195; e-mail: lachhwd{at}ccf.org

Prolonged high-dose suppressive therapy (HDST) is a mainstay in the management of refractory status epilepticus (RSE), albeit with high morbidity and mortality. The authors studied 10 patients who were carefully selected for epilepsy surgery after failing prolonged (>2 weeks) HDST. Status epilepticus was stopped acutely in all of them with no mortality and no substantial morbidity. At follow-up (median 7 months), 7 (70%) of 10 patients were seizure free, and 3 (30%) of 10 had significant improvement in their epilepsy.

Received April 30, 2004. Accepted in final form September 15, 2004.




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