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NEUROLOGY 2005;64:670-674
© 2005 American Academy of Neurology

"Off" gait freezing and temporal discrimination threshold in patients with Parkinson disease

Myung-Sik Lee, MD, PhD, Hyun-Sook Kim, MD and Chul-Hyoung Lyoo, MD

From the Department of Neurology, Youngdong Severance Hospital, Brain Korea 21 Project for Medical Science, Yonsei University, Seoul, Korea.

Address correspondence and reprint requests to Dr. Myung-Sik Lee, Department of Neurology, Youngdong Severance Hospital, 146-92 Dogok-dong, Kangnam-gu, Seoul, Korea; e-mail: myungs56{at}yumc.yonsei.ac.kr

Objective: To investigate the relationship between temporal discrimination threshold (TDT) and "off" period gait freezing (OGF) in patients with fluctuating Parkinson disease (PD).

Methods: TDT values were measured at the dorsum of the toes in 11 control subjects and 22 patients with PD with a wearing-off phenomenon (16 patients with OGF and 6 patients without OGF).

Results: During the l-dopa "off" period, TDT values increased abnormally in both patient groups but were significantly higher in patients with OGF than in those without OGF. A positive correlation was found between the severity of OGF and TDT values measured by different point stimulation. In patients with OGF, a single dose of l-dopa treatment normalized TDT values and ameliorated OGF.

Conclusions: Dopa-responsive abnormal discriminative sensory processing may be a possible cause of "off" period gait freezing observed in patients with fluctuating Parkinson disease.






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