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NEUROLOGY 2005;64:707-709
© 2005 American Academy of Neurology
Brief Communications

Steroid dementia: An overlooked diagnosis?

Oliver Sacks, MD and Melanie Shulman, MD

From Albert Einstein College of Medicine (Dr. Sacks), Bronx; and NYU Medical Center (Drs. Sacks and Shulman), New York, NY.

Address correspondence and reprint requests to Dr. Oliver Sacks, 2 Horatio Street, Apt. 3G, New York, NY 10014; e-mail: mail{at}oliversacks.com

The authors studied a 72-year-old man with polymyalgia rheumatica who, after taking 100 mg of prednisone for 3 months, developed a psychosis followed by dementia. It was initially considered that the dementia was a separate neurodegenerative condition, probably of Alzheimer type, but when steroids were discontinued, he rapidly returned to his previous level of functioning. Reviewing the literature regarding the effects of steroids on cerebral function, the authors found that such cases of "reversible dementia" are not uncommon, although rarely given the emphasis they deserve. The authors believe, given the extensive use of steroids in medical practice, that physicians should be more aware of this important cause of reversible dementia.


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C. Norra, M. Arndt, H. J. Kunert, O. Sacks, and M. Shulman
Steroid dementia: An overlooked diagnosis?
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Correspondence:

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Steroid dementia: An overlooked diagnosis?
Christine Norra, MD, et al.
Neurology Online, 13 Jun 2005 [Full text]
Reply to Norra et al
Oliver Sacks, M.D., et al.
Neurology Online, 13 Jun 2005 [Full text]

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