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NEUROLOGY 2005;64:713-715
© 2005 American Academy of Neurology
Brief Communications

Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial

P. S. Sándor, MD, L. Di Clemente, MD, G. Coppola, MD, U. Saenger, A. Fumal, MD, D. Magis, MD, L. Seidel, MSc, R. M. Agosti, MD and J. Schoenen, MD, PhD

From the Headache and Pain Unit (Drs. Sándor and Agosti, U. Saenger), Neurology Department, University Hospital Zurich; Zurich Hirslanden Headache Center (Dr. Agosti, U. Saenger), Zurich, Switzerland; Department of Neurology (Drs. Schoenen, Di Clemente, Coppola, Fumal, and Magis), CHR Citadelle, Liège; and Department of Biostatistics and Medical Informatics (L. Seidel), CHU Sart Tilman, University of Liège, Liège, Belgium.

Address correspondence and reprint requests to Dr. med. Peter S. Sándor, Headache and Pain Unit, Neurology Department, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.


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