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Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study

From the Division of Endocrinology, Diabetes, and Nutrition (Drs. VanItallie and Heymsfield, K. Hyams), Department of Medicine, St. Luke’s-Roosevelt Hospital Center, New York; Department of Medicine (C. Nonas), North General Hospital, New York; and Movement Disorders Clinic (Dr. Di Rocco, K. Boyar), Department of Neurology, Beth Israel Medical Center, New York.

Address correspondence and reprint requests to Dr. Theodore B. VanItallie, P.O. Box 775, Boca Grande, FL 33921-0775; e-mail: tedvani{at}ewol.com

Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson’s Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out.

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