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Mortality following a first unprovoked seizure in children: A prospective study

From the Departments of Neurology (Dr. Shinnar, C. O’Dell), Pediatrics (Dr. Shinnar), and Nursing (C. O’Dell) and the Comprehensive Epilepsy Management Center (Dr. Shinnar, C. O’Dell), Montefiore Medical Center, The Albert Einstein College of Medicine, Bronx, NY; Department of Biological Sciences (Dr. Berg), Northern Illinois University, DeKalb.

Address correspondence and reprint requests to Dr. Shlomo Shinnar, Epilepsy Management Center, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467; e-mail: SShinnar{at}aol.com

In a prospective study, 407 children with a first unprovoked seizure were followed for a mean of 14.2 years. To date, nine have died. Death was unrelated to seizures in four subjects who had no further seizures and were on no medications. The remaining five subjects all had multiple seizures and were on medications. Treatment following the first seizure would not have altered mortality in any of the nine cases.

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