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NEUROLOGY 2005;64:885-887
© 2005 American Academy of Neurology
Brief Communications

MRI brain volumetry in Rasmussen encephalitis: The fate of affected and "unaffected" hemispheres

S. Larionov, MD, R. König, MD, H. Urbach, MD, R. Sassen, MD, C. E. Elger, MD, FRCP and C. G. Bien, MD

From the Departments of Neuropathology (Dr. Larionov), Radiology/Neuroradiology (Drs. König, and Urbach), and Epileptology (Drs. Sassen, Elger, and Bien), University of Bonn, Germany.

Address correspondence and reprint requests to Dr. Christian Bien, Department of Epileptology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany; e-mail: c.bien{at}uni-bonn.de

Rasmussen encephalitis (RE) is regarded as a unihemispheric disease. Serial three-dimensional MRIs of 18 patients under immunotherapy were analyzed volumetrically and planimetrically. Median volume loss was significantly higher in the affected than in the unaffected hemispheres (29.9 cm3/y vs 6.8 cm3/y). Correlation of the planimetrically and volumetrically assessed hemispheric ratios (HRs) was significant. The results support the concept of RE as a basically unilateral disease. Planimetric HR assessment is valid and time efficient.