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Alzheimer disease and cancer

From the Division of Biostatistics (Drs. Roe and Xiong, J.P. Miller), Washington University School of Medicine, St. Louis, MO; Alzheimer’s Disease Research Center (Drs. Roe, Behrens, Xiong, and Morris, J.P. Miller), Washington University School of Medicine, St. Louis, MO; Departamento de Neurología y Neurocirugía (Dr. Behrens), Hospital Clínico Universidad de Chile and Clínica Alemana de Santiago, Santiago, Chile; Departments of Neurology, Pathology and Immunology, and Physical Therapy (Dr. Morris), Washington University School of Medicine, St. Louis, MO.

Address correspondence and reprint requests to Dr. Catherine M. Roe, Division of Biostatistics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8067, St. Louis, MO 63110; e-mail: cathyr{at}wubios.wustl.edu

Cross-sectional studies raise the possibility of protective relationships between, or a common mechanism underlying, the development of dementia of the Alzheimer type (DAT) and cancer. Using a prospective longitudinal design, the authors found that the risk of developing cancer is less among participants with DAT vs nondemented participants (p < 0.001) and that the risk of developing DAT may be less for participants with a history of cancer (p = 0.060).

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