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NEUROLOGY 2005;64:899-901
© 2005 American Academy of Neurology
Brief Communications

Hypertension and cognitive performance in African Americans with Alzheimer disease

F. C. Goldstein, PhD, A. V. Ashley, MD, L. J. Freedman, MD, PhD, L. Penix, MD, J. J. Lah, MD, PhD, J. Hanfelt, PhD and A. I. Levey, MD, PhD

From the Department of Neurology (Drs. Goldstein, Ashley, Freedman, Lah, and Levey), Emory University School of Medicine; Department of Biostatistics (Dr. Hanfelt), Emory University; and the Neuroscience Institute (Dr. Penix), Morehouse School of Medicine, Atlanta, GA.

Address correspondence and reprint requests to Dr. F.C. Goldstein, Department of Neurology, Emory University School of Medicine, 1841 Clifton Road, N.E., Atlanta, GA 30329; e-mail: fgoldst{at}emory.edu

The authors examined the relationship between hypertension and cognitive performance in 34 African-American patients with probable Alzheimer disease. Multiple regression analyses indicated that hypertension was associated with poorer overall performance on the Mattis Dementia Rating Scale, particularly the Initiation/Perseveration and Conceptualization subscales, after controlling for gender, age, and education. The findings suggest that African-American patients with hypertension exhibit greater cognitive impairment, possibly reflecting executive dysfunction.


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