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Chronic inflammatory demyelinating polyradiculoneuropathy: MRI study of brain and spinal cord

From the Centre for Neuromuscular Disease and Department of Molecular Neurosciences (Drs. Laura, Leong, and Reilly), Department of Clinical Neurophysiology (Dr. Murray), National Hospital for Neurology and Neurosurgery, and NMR Research Unit (Drs. Ingle, Miszkiel, Altmann, and Miller), Institute of Neurology (Drs. Laura, Leong, and Reilly), University College London, and London School of Hygiene and Tropical Medicine (Dr. Altmann), UK; and Department of Research and Diagnostic (Dr. Laura), National Neurological Institute C. Besta, Milan, Italy.

Address correspondence and reprint requests to Dr. M.M. Reilly, Centre for Neuromuscular Diseases and Department of Molecular Neurosciences, National Hospital for Neurology and Neurosurgery and Institute of Neurology, Queen Square, London, WC1N 3BG, UK; e-mail: m.reilly{at}ion.ucl.ac.uk

CNS demyelinating lesions have been reported in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). There are no studies of cord atrophy in CIDP. Ten patients with CIDP underwent brain and spinal cord MRI to investigate CNS demyelination and cord atrophy. No CNS demyelination was found, but the mean cervical cord area was significantly smaller in CIDP patients vs control subjects. Spinal cord atrophy may be related to degeneration secondary to axonal loss.

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				Y. Iwasaki, O. Igarashi, J. Aoyagi, K. Iwamoto, K. Ikeda, M. M. Reilly, and M. Laura Chronic inflammatory demyelinating polyradiculoneuropathy: MRI study of brain and spinal cord Neurology, October 25, 2005; 65(8): 1340 - 1340. [Full Text] [PDF]

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