Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meschia, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meschia, J. F.
Related Collections
Right arrow All Cerebrovascular disease/Stroke
Right arrow Infarction
Right arrow All Genetics
NEUROLOGY 2005;64:1061-1063
© 2005 American Academy of Neurology
Brief Communications

Correlation of proband and sibling stroke latency: The SWISS Study

J. F. Meschia, MD, T. G. Brott, MD, R. D. Brown, Jr, MD, B. M. Kissela, MD, J. A. Hardy, PhD, W. M. Brown, MA, S. S. Rich, PhD for the Siblings With Ischemic Stroke Study Investigators*

From the Department of Neurology (Drs. Meschia and Brott), Mayo Clinic, Jacksonville, FL; Department of Neurology (Dr. Brown), Mayo Clinic, Rochester, MN; Department of Neurology (Dr. Kissela), University of Cincinnati, OH; National Institute on Aging (Dr. Hardy), Bethesda, MD; and Department of Biostatistics (Dr. Rich, W.M. Brown), Wake Forest University School of Medicine, Winston-Salem, NC.

Address correspondence and reprint requests to Dr. James F. Meschia, Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224; e-mail: Meschia.James{at}mayo.edu

The authors found a correlation between the age at which probands experience an incident stroke and the age at which their siblings experience an incident stroke (r = 0.68; p < 0.0001). Proband-sibling incident stroke latency correlations were observed in analyses restricted to siblings concordant for smoking (r = 0.68; p < 0.0001), diabetes (r = 0.73; p < 0.0001), and hypertension (r = 0.63; p < 0.0001). In the authors’ cohort of affected sibling pairs, inherited factors were important determinants of incident ischemic stroke latency.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the March 22 issue to find the title link for this article.

*See the Appendix on the Neurology Web site for a list of participating centers and investigators.

Supported by a grant from the National Institute of Neurological Disorders and Stroke (R01 NS39987 to J.F.M.). The funding source had no involvement in study design beyond initial peer review of the grant. The funding source had no involvement in collection, analysis, or interpretation of data; in writing of the report; or in the decision to submit the article for publication.

Received July 28, 2004. Accepted in final form November 30, 2004.




This article has been cited by other articles:


Home page
 StrokeHome page
K. Sundquist, X. Li, and K. Hemminki
Familial Risk of Ischemic and Hemorrhagic Stroke: A Large-Scale Study of the Swedish Population
Stroke, July 1, 2006; 37(7): 1668 - 1673.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by AAN Enterprises, Inc.