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NEUROLOGY 2005;64:1073-1075
© 2005 American Academy of Neurology
Brief Communications

In situ identification of hepatitis C virus RNA in muscle

H. Ito, MD, H. Ito, MD, PhD, M. Nagano, PhD, S. Nakano, MD, PhD, Y. Shigeyoshi, MD, PhD and H. Kusaka, MD, PhD

From the Department of Neurology (Drs. Ito, Ito, Nakano, and Kusaka), Kansai Medical University, Moriguchi, Osaka, Japan; and Second Department of Anatomy and Neurobiology (Drs. Nagano and Shigeyoshi), Kinki University School of Medicine, Osaka, Japan.

Address correspondence and reprint requests to Dr. Hisashi Ito, Department of Neurology, Kansai Medical University, 10-15, Fumizono-cho, Moriguchi, Osaka, 570-8507, Japan; e-mail: itohi{at}takii.kmu.ac.jp

The authors examined skeletal muscle specimens from four patients with myositis and hepatitis C virus (HCV) infection. PCR analysis identified HCV RNA in muscle homogenates from two patients. In situ hybridization signals for HCV RNA were detected within muscle fibers as well as in infiltrating lymphocytes from the same patients. The results may relate to the pathomechanism of myositis in patients with HCV infection.

Supported in part by a grant from the Japan Society for the Promotion of Science (No. 15590917).

Received June 14, 2004. Accepted in final form November 19, 2004.






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