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The effect of levetiracetam on essential tremor

From the Neurology Service, Minneapolis Veterans Affairs Medical Center, MN.

Address correspondence and reprint requests to Dr. K. Bushara, Neurology Service (127), Minneapolis Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417; e-mail: busha001{at}umn.edu

The effect of a single dose of 1,000 mg of levetiracetam on essential tremor was investigated in 24 patients in a double-blind, placebo-controlled trial. There was a significant reduction of hand tremor for at least 2 hours as measured by accelerometry and functional tests.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the March 22 issue to find the link for this article.

Supported by the Department of Veterans Affairs and an investigator-initiated study grant from UCB-Pharma. K.O.B. and R.E.E. have received honoraria from UCB-Pharma.

Received January 6, 2004. Accepted in final form November 23, 2004.

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