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From the Departments of Neurology and Surgery, Tufts-New England Medical Center, Boston, MA.
Address correspondence and reprint requests to Dr. P.R. Bergethon, Department of Neurology, Tufts-New England Medical Center, 750 Washington Street, Box 314, Boston, MA 02111; e-mail: pbergethon{at}tufts-nemc.org
Seizures may occur after orthotopic liver transplantation. Antiepileptic drugs (AEDs) are used to treat these seizures, but the immunosuppressant regimen also may be altered. Levetiracetam is an attractive treatment because of its efficacy, lack of hepatic enzyme induction, and its rapid attainment of serum levels. Treatment with levetiracetam is efficacious, and levetiracetam-treated patients require significantly lower doses of immunosuppressant medications to achieve an equivalent antirejection effect.
Supported by a grant from UCB Pharma, Smyrna, GA. R.F. has received grants and P.R.B. has received honoraria from UCB Pharma.
Received June 17, 2004. Accepted in final form November 22, 2004.
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