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Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen

From the Departments of Neurology (Drs. Schuele, Kellinghaus, Shook, Bethoux, and Loddenkemper) and Neurosurgery (Dr. Boulis), The Cleveland Clinic Foundation, Cleveland, OH.

Address correspondence and reprint requests to Dr. Stephan Schuele, Department of Neurology/S91, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: schules{at}ccf.org

Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures. The authors observed a higher incidence of epileptic seizures in 99 patients with multiple sclerosis (MS) treated with ITB vs a matched control group (7% vs 1%, p < 0.05). Three patients with MS on ITB developed status epilepticus. Seizures were often associated with additional triggering factors.

Supported by Innovative Medizinische Forschung, WWU Münster (FoeKz. LO 610101/KE 620101) (Drs. Loddenkemper and. Kellinghaus), and NRW-Nachwuchsgruppe Kn2000, Federal Ministry of Education and Research (Foe 1KS9604/0), and Interdisciplinary Center of Clinical Research Münster (IZKF Project NWG2) (Dr. Loddenkemper).

Presented in part at the American Epilepsy Society Annual Meetings, Seattle, WA, December 2002, and Boston, MA, December 2003.

Received August 4, 2004. Accepted in final form November 19, 2004.

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