Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Related articles in Neurology
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kobayashi, E.
Right arrow Articles by Dubeau, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kobayashi, E.
Right arrow Articles by Dubeau, F.
Related Collections
Right arrow fMRI
Right arrow All Epilepsy/Seizures
Right arrow EEG
Right arrow Video/ EEG use in epilepsy
Right arrow Epileptogenic zone
Right arrow Cortical localization
NEUROLOGY 2005;64:1263-1266
© 2005 American Academy of Neurology
Brief Communications

Intrinsic epileptogenicity in polymicrogyric cortex suggested by EEG-fMRI BOLD responses

E. Kobayashi, MD, PhD, A. P. Bagshaw, PhD, A. Jansen, MD, F. Andermann, MD, FRCP(C), E. Andermann, MD, PhD, FCCMG, J. Gotman, PhD and F. Dubeau, MD, FRCP(C)

From the Department of Neurology and Neurosurgery (Drs. Kobayashi, Bagshaw, Jansen, F. Andermann, E. Andermann, Gotman, and Dubeau), Human Genetics (Dr. E. Andermann), and Pediatrics (Dr. F. Andermann), Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

Address correspondence and reprint requests to Dr. Eliane Kobayashi, Montreal Neurologic Institute and Hospital, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4; e-mail: eliane.kobayashi{at}mail.mcgill.ca

Polymicrogyria (PMG) is a widespread cortical malformation frequently associated with seizures and EEG spikes. Its epileptogenicity is poorly understood. Nine patients with simultaneous EEG and fMRI were studied to assess the blood oxygenation level-dependent response to spikes. Sixteen of 18 studies showed responses, with maximum activation involving the lesion in 61.5%, but often limited to a small fraction of that lesion, suggesting intrinsic epileptogenicity in small areas of the PMG cortex.

Editorial, see page 1108

See also page 1125

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the April 12 issue to find the title link for this article.

Supported by the Canadian Institutes of Health Research (CIHR) under grant MOP-38079. E.K. received a Preston Robb fellowship from the Montreal Neurologic Institute and is presently the recipient of a postdoctoral fellowship from the CIHR. A.J. was funded by the Fondation de la Vocation/Belgische Stichting Roeping and is presently the recipient of a postdoctoral fellowship from the Savoy Foundation for Epilepsy.

Received September 28, 2004.

Accepted in final form November 30, 2004.


Related articles in Neurology:

April 12 Highlights

Neurology 2005 64: 1106-1107. [Full Text]  

A multilayered approach to studying cortical malformations: EEG-fMRI
John A. Detre and Peter B. Crino
Neurology 2005 64: 1108-1110. [Full Text]  

Cortical/subcortical BOLD changes associated with epileptic discharges: An EEG-fMRI study at 3 T
Paolo Federico, John S. Archer, David F. Abbott, and Graeme D. Jackson
Neurology 2005 64: 1125-1130. [Abstract] [Full Text]  



This article has been cited by other articles:


Home page
 BrainHome page
L. Tyvaert, C. Hawco, E. Kobayashi, P. LeVan, F. Dubeau, and J. Gotman
Different structures involved during ictal and interictal epileptic activity in malformations of cortical development: an EEG-fMRI study
Brain, August 1, 2008; 131(8): 2042 - 2060.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. S. Briellmann, T. Little, A. S. Harvey, D. F. Abbott, R. Jacobs, A. B. Waites, and G. D. Jackson
Pathologic and physiologic function in the subcortical band of double cortex.
Neurology, September 26, 2006; 67(6): 1090 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
E. Kobayashi, A. P. Bagshaw, C. Grova, J. Gotman, and F. Dubeau
Grey matter heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders
Brain, February 1, 2006; 129(2): 366 - 374.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. A. Detre and P. B. Crino
A multilayered approach to studying cortical malformations: EEG-fMRI
Neurology, April 12, 2005; 64(7): 1108 - 1110.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by AAN Enterprises, Inc.