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From University of California, San Francisco.
Address correspondence and reprint requests to Dr. Bruce A.C. Cree, Multiple Sclerosis Center at UCSF, 350 Parnassus Ave., Suite 908, San Francisco, CA 94117; e-mail: bcree{at}itsa.ucsf.edu
Eight patients with worsening neuromyelitis optica were treated with rituximab to achieve B cell depletion. Treatment was well tolerated. Six of eight patients were relapse free and median attack rate declined from 2.6 attacks/patient/year to 0 attacks/patient/year (p = 0.0078). Seven of eight patients experienced substantial recovery of neurologic function over 1 year of average follow-up. The pretreatment median Expanded Disability Status Scale score was 7.5, and at follow-up examination was 5.5 (p = 0.013).
Bruce Cree’s contribution was supported in part by the Sylvia Lawry postdoctoral fellowship grant from the National Multiple Sclerosis Society.
Received December 30, 2004. Accepted in final form January 30, 2005.
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