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NEUROLOGY 2005;64:1273-1275
© 2005 American Academy of Neurology


Brief Communications

Encephalopathy and peripheral neuropathy following diethylene glycol ingestion

M. J. Hasbani, MD, PhD, L. H. Sansing, MD, J. Perrone, MD, A. K. Asbury, MD and S. J. Bird, MD

From the Departments of Neurology (Drs. Hasbani, Sansing, Asbury, and Bird) and Emergency Medicine (Dr. Perrone), University of Pennsylvania School of Medicine, Philadelphia, PA.

Address correspondence and reprint requests to Dr. M.J. Hasbani, Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce St., 3 West Gates, Philadelphia, PA 19104-4283; e-mail: hasbani2001{at}yahoo.com

The authors report a 24-year-old man who developed encephalopathy and rapid quadriplegia following ingestion of a solution containing diethylene glycol (DEG). As quadriparesis evolved, motor response amplitudes were markedly reduced with preserved conduction velocities. Studies during clinical recovery revealed marked motor conduction velocity slowing and prolonged distal latencies. These data indicate that DEG intoxication may cause a primary acute axonal sensorimotor polyneuropathy with demyelinating physiology during recovery.


Received September 19, 2004. Accepted in final form December 13, 2004.




This article has been cited by other articles:


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G. P. Daubert, A. Katiyar, J. Wilson, L. Baltarowich, M.J. Hasbani, L. Sansing-Hachmann, J. Perrone, A.K. Asbury, and S.J. Bird
Encephalopathy and peripheral neuropathy following diethylene glycol ingestion
Neurology, March 14, 2006; 66(5): 782 - 783.
[Full Text] [PDF]

Correspondence:

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Encephalopathy and peripheral neuropathy following diethylene glycol ingestion
G. Patrick Daubert, MD, et al.
Neurology Online, 11 Oct 2005 [Full text]
Reply from the authors
M. Josh Hasbani, MD, PhD, et al.
Neurology Online, 11 Oct 2005 [Full text]



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