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Microbleeds in hereditary cerebral hemorrhage with amyloidosis- Dutch type

From the Departments of Radiology (Drs. van den Boom, Behloul, and van Buchem, A.A. van den Berg-Huysmans) and Neurology (Dr. Haan), Leiden University Medical Center, Department of Neurology (Dr. Haan), Rijnland Hospital, Leiderdorp, Department of Epidemiology and Biostatistics (Dr. Bornebroek), Erasmus Medical Center, Rotterdam, and Department of Neurology (Dr. Bornebroek), Vlietland Hospital, Schiedam, the Netherlands.

Address correspondence and reprint requests to Dr. R. van den Boom, Department of Radiology, Leiden University Medical Center, C2S, Albinusdreef 2, 2333 ZA Leiden, the Netherlands; e-mail: r.van_den_boom{at}lumc.nl

In a hereditary variant of cerebral amyloid angiopathy (CAA), cerebral hemorrhage with amyloidosis-Dutch type, supratentorial microbleeds were found to occur independently of the presence of hypertension, whereas hypertension probably contributed to the development of cerebellar microbleeds. This predictable hereditary variant of CAA may be a useful model to study microbleeds in relation to CAA.

Received March 22, 2004. Accepted in final form December 24, 2004.

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