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NEUROLOGY 2005;64:1301-1303
© 2005 American Academy of Neurology
Brief Communications

Smoking affects the phenotype of Alzheimer disease

M. N. Sabbagh, MD, S. L. Tyas, PhD, S. C. Emery, MD, L. A. Hansen, MD, M. F. Alford, BA, R. T. Reid, PhD, P. Tiraboschi, MD and L. J. Thal, MD

From The Cleo Roberts Center for Clinical Research (Dr. Sabbagh), Sun Health Research Institute, Sun City, AZ; Department of Neurosciences (Drs. Emery, Hansen, Alford, Tiraboschi, Thal), University of California San Diego, La Jolla; Graduate Center for Gerontology and Department of Epidemiology (Dr. Tyas), University of Kentucky, Lexington; Banck Clinical Research Center (Dr. Reid), San Diego, CA; Ospedale Ca’ Granda (Dr. Tiraboschi), Niguarda, Milan, Italy

Address correspondence and reprint requests to Dr. Marwan N. Sabbagh, The Cleo Roberts Center for Clinical Research, Sun Health Research Institute, 10515 W. Santa Fe Drive, Sun City, AZ 85351; e-mail: Marwan.Sabbagh{at}sunhealth.org

Because epidemiologic and in vitro evidence conflict, the authors studied the association between smoking and Alzheimer disease (AD) in 46 never, 47 former, and 15 active smokers with AD followed to autopsy. Disease parameters were examined by smoking status and amount smoked in bivariate tests and in multivariate models controlling for age, sex, education, and APOE status. Smoking status was not associated with cognitive or neuropathologic measures. However, active smokers were significantly younger at death and higher levels of smoking were associated with shorter disease duration.

Supported by AG05131, AG019610, and the Sun Health Research Institute.

Received July 2, 2004. Accepted in final form December 8, 2004.






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