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This Article Figures Only Full Text Full Text (PDF) CME: Take the course for this article: Volume 64, Number 8, April 26, 2005 All Versions of this Article: 01.WNL.0000158328.26897.0Dv1 64/8/1343    most recent Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cherner, M. Search for Related Content PubMed PubMed Citation Articles by Cherner, M.

Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine

From the Departments of Psychiatry (Drs. Cherner, Heaton, and Grant) and Medicine (Dr. Letendre, J. Durelle, J. Marquie-Beck, and B. Gragg), University of California San Diego, and VA San Diego Healthcare System (Dr. Grant), CA.

Address correspondence and reprint requests to Dr. M. Cherner, University of California San Diego, 150 W. Washington St., 2nd fl., San Diego, CA 92103; e-mail: mcherner{at}ucsd.edu

Objective: To examine the contribution of hepatitis C virus (HCV) infection to neurocognitive dysfunction in individuals with comorbid HIV infection or methamphetamine (METH) dependence.

Methods: Neurocognitive functioning was examined in 430 study participants who were either normal controls or had HCV infection, HIV infection, history of METH dependence, or combinations of these factors as risks for cognitive deficits.

Results: Rates of global and domain-specific neuropsychological (NP) impairment increased with the number of risk factors. HCV serostatus was a significant predictor of NP performance both globally and in the areas of learning, abstraction, and motor skills, with trends in speeded information processing and delayed recall. HCV serostatus did not predict scores in attention/working memory or verbal fluency.

Conclusion: Hepatitis C virus infection contributes to the neuropsychological deficits observed among HIV-infected and stimulant-dependent populations.

Editorial, see page 1328

Supported by the National Institute on Drug Abuse (P01 DA12065, R01 DA16015).

Received June 2, 2004. Accepted in final form December 13, 2004.

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