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Published online before print April 7, 2005, doi:10.1212/01.WNL.0000158328.26897.0D)
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 Volume 64, Number 8, April 26, 2005
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NEUROLOGY 2005;64:1343-1347
© 2005 American Academy of Neurology

Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine

M. Cherner, PhD, S. Letendre, MD, R. K. Heaton, PhD, J. Durelle, BS, J. Marquie-Beck, BA, B. Gragg, BS, I. Grant, MD and the HIV Neurobehavioral Research Center Group

From the Departments of Psychiatry (Drs. Cherner, Heaton, and Grant) and Medicine (Dr. Letendre, J. Durelle, J. Marquie-Beck, and B. Gragg), University of California San Diego, and VA San Diego Healthcare System (Dr. Grant), CA.

Address correspondence and reprint requests to Dr. M. Cherner, University of California San Diego, 150 W. Washington St., 2nd fl., San Diego, CA 92103; e-mail: mcherner{at}ucsd.edu

Objective: To examine the contribution of hepatitis C virus (HCV) infection to neurocognitive dysfunction in individuals with comorbid HIV infection or methamphetamine (METH) dependence.

Methods: Neurocognitive functioning was examined in 430 study participants who were either normal controls or had HCV infection, HIV infection, history of METH dependence, or combinations of these factors as risks for cognitive deficits.

Results: Rates of global and domain-specific neuropsychological (NP) impairment increased with the number of risk factors. HCV serostatus was a significant predictor of NP performance both globally and in the areas of learning, abstraction, and motor skills, with trends in speeded information processing and delayed recall. HCV serostatus did not predict scores in attention/working memory or verbal fluency.

Conclusion: Hepatitis C virus infection contributes to the neuropsychological deficits observed among HIV-infected and stimulant-dependent populations.

Editorial, see page 1328

Supported by the National Institute on Drug Abuse (P01 DA12065, R01 DA16015).

Received June 2, 2004. Accepted in final form December 13, 2004.




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