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From the Institute for Research in Extramural Medicine (EMGO Institute) (Drs. Dik, Jonker, and Comijs) and the Departments of Psychiatry (Drs. Jonker, Smit, Comjis, and Eikelenboom), Clinical Chemistry (Dr. Hack), and Social Sciences (Dr. Smit), VU University Medical Center, Amsterdam, the Netherlands; and Department of Immunopathology (Dr. Hack), Sanquin Research at the CLB, Amsterdam, the Netherlands.
Address correspondence and reprint requests to Dr. M. G. Dik, VU University Medical Center, LASA H-065, Van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands; e-mail: mg.dik{at}vumc.nl
Objective: To assess whether serum levels of the inflammatory proteins 
1-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons.
Methods: The study sample consisted of 1,284 participants in the Longitudinal Aging Study Amsterdam, aged 62 to 85 years. Cognition was assessed on general cognition (Mini-Mental State Examination [MMSE]), memory (Auditory Verbal Learning Test), fluid intelligence (Raven’s Colored Progressive Matrices), and information-processing speed (Coding Task) at baseline and at 3-year follow-up.
Results: The highest tertile of ACT was associated with an increased risk of decline on the MMSE (age-, sex-, education-adjusted odds ratio [OR] 1.60; 95% CI: 1.05 to 2.43) but not on any other cognitive test score. CRP, IL-6, and albumin were not associated with cognitive decline on any cognitive test in our study.
Conclusions: This population-based study showed that the serum inflammatory protein 1-antichymotrypsin is associated with cognitive decline in older persons, whereas C-reactive protein, interleukin-6, and albumin are not.
The Longitudinal Aging Study Amsterdam is funded by the Dutch Ministry of Health, Welfare, and Sports and the Vrije Universiteit. The study on inflammation and cognition is supported by the Internationale Stichting Alzheimer Onderzoek (grant no. 01501), and the Alzheimer Center of the VU University Medical Center.
Received September 10, 2004. Accepted in final form December 30, 2004.
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