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Cognitive functioning in children and adolescents with multiple sclerosis

From State University of New York at Stony Brook (Drs. MacAllister, Krupp, Belman, Weisbrot, Christodoulou, and Preston, and M. Milazzo and W.F. Scherl); St. Charles Rehabilitation Hospital (Dr. Preston), Long Island, NY; and Weldon Rehabilitation Hospital-Mercy Medical Center (Dr. Cianciulli), Springfield, MA.

Address correspondence and reprint requests to Dr. Lauren B. Krupp, State University of New York at Stony Brook, HSC T-12 020, Department of Neurology, Stony Brook, NY 11794-8121; e-mail: lkrupp{at}notes.cc.sunysb.edu

Objective: To examine cognitive functioning in children with multiple sclerosis (MS).

Methods: The authors examined the neuropsychological profile of 37 children with a diagnosis of clinically definite MS and assessed the associations between cognitive function and clinical features.

Results: Of 37 children and adolescents evaluated, 35% demonstrated significant cognitive impairment. Cognitive functioning was strongly related to several clinical variables, including current Expanded Disability Status Scale, total number of relapses, and total disease length. The consequences of MS adversely affected academic functioning in over a third of the children.

Conclusions: Cognitive deficits occur in children with multiple sclerosis. Comprehensive treatment planning should involve recognition that they may require academic accommodations for their education.

Supported in part by National MS Society Pilot Grant PP 0773 and the National Center for Research Resources (Grant # M01-RR10710).

Received July 14, 2004. Accepted in final form January 3, 2005.

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