Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Polish Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roine, S.
Right arrow Articles by Viitanen, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roine, S.
Right arrow Articles by Viitanen, M.
NEUROLOGY 2005;64:1441-1443
© 2005 American Academy of Neurology
Brief Communications

Neurologic symptoms are common during gestation and puerperium in CADASIL

S. Roine, MD, M. Pöyhönen, MD, PhD, S. Timonen, MD, PhD, S. Tuisku, MD, R. Marttila, MD, PhD, R. Sulkava, MD, PhD, H. Kalimo, MD, PhD and M. Viitanen, MD, PhD

From the Departments of Neurology (Drs. Roine and Marttila), Obstetrics and Gynaecology (Dr. Timonen), and Pathology (Dr. Kalimo), University and University Hospital of Turku, and Department of Geriatric Medicine (Dr. Viitanen), University of Turku, Department of Medical Genetics (Dr. Pöyhönen), Family Federation of Finland, Helsinki, Department of Neurology (Dr. Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Department of Public Health and General Practice (Dr. Sulkava), University of Kuopio, and Department of Pathology (Dr. Kalimo), University and University Hospital of Helsinki, Finland; and Division of Clinical Geriatrics (Dr. Viitanen), Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Address correspondence and reprint requests to Dr. H. Kalimo, Department of Pathology, University and University Hospital of Helsinki, FI-00014 Helsinki, Finland; e-mail: hannu.kalimo{at}helsinki.fi

Based on a structured questionnaire and medical records, the authors found that 12 of 25 mothers with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with the R133C NOTCH3 mutation had had neurologic symptoms in 17 of their 43 pregnancies, most commonly hemiparesthesia (76%), hemiparesis (36%), aphasia (65%), and visual disorders (47%). In 82% of the patients, the symptoms were the first manifestation of CADASIL. The symptoms were most common during puerperium and in patients older than age 30.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the April 26 issue to find the title link for this article.

Received March 29, 2004. Accepted in final form December 27, 2004.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by AAN Enterprises, Inc.