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NEUROLOGY 2005;64:1446-1449
© 2005 American Academy of Neurology
Brief Communications

Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex

Kevin C. Ess, MD, PhD, Christine A. Kamp, BS, Benjamin P. Tu, MD, PhD and David H. Gutmann, MD, PhD

From the Departments of Neurology (Drs. Ess and Gutmann, and C.A. Kamp) and Pathology (Dr. Tu), Division of Neuropathology, Washington University School of Medicine, St. Louis, MO.

Address correspondence and reprint requests to Dr. David H. Gutmann, Department of Neurology, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110; e-mail: gutmannd{at}neuro.wustl.edu

Children with tuberous sclerosis complex (TSC) harbor developmental brain abnormalities (cortical tubers) and low-grade tumors (subependymal giant cell astrocytomas [SEGAs]). Using gene expression profiling to identify neuroglial differentiation markers in Tsc1 conditional knockout mice, the authors demonstrate that giant cells of SEGAs aberrantly express similar neuroglial differentiation markers as do cortical tubers. These results suggest that both tubers and SEGAs result from related defects in progenitor cell differentiation during brain development.

Supported by grants from the Department of Defense (DAMD17–03–1–0073; D.H.G.) and the National Institutes of Health (5T32-NS07205–21; K.C.E.).

Received September 16, 2004. Accepted in final form December 30, 2004.




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